Wednesday, September 24, 2025

Breaking Ground: 4D Mammography Trials Start at Baptist Health Hardin

 

Baptist Health Hardin in Elizabethtown, Kentucky has become the first hospital in the world to begin in-human trials of 4D Mammography technology, marking a potential breakthrough in the early detection and diagnosis of breast cancer.

The new imaging system, developed by Calidar Inc.—a Duke University start-up specializing in clinical X-ray diffraction—moves beyond the limitations of traditional mammography. Instead of relying solely on images of breast tissue, 4D Mammography uses X-ray diffraction to analyze the molecular “fingerprints” of tissue, offering a clearer and less invasive path to identifying breast cancer.

“This groundbreaking research has the potential to change the course of treatment for countless people,” said Bert Jones, Director of Medical Imaging at Baptist Health Hardin. “Being part of this pivotal moment in medical innovation represents more than just scientific progress — it’s a step forward in improving the lives of women everywhere.”

The clinical trial at Baptist Health Hardin, launched on August 19, will include about 60 patients. Researchers will evaluate both the efficiency and accuracy of the technology before it can move toward wider approval and eventual commercial use.

Dr. Stefan Stryker, CEO of Calidar, emphasized the significance of applying X-ray diffraction to medicine:

“X-ray diffraction has unlocked some of the most iconic achievements in science — from the structure of DNA to discoveries on Mars. Now, we are bringing that power into the clinic to look inside the human body in a completely new way.”

While not yet FDA-approved, the promise of 4D Mammography could redefine how clinicians detect breast cancer—potentially reducing the need for invasive procedures, minimizing delays in diagnosis, and creating a new standard in breast cancer screenings worldwide.

Learn more about this study on the Calidar website.

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Written by the Digital Marketing Team at Creative Programs & Systems: https://www.cpsmi.com/.

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